OncoK9 – Case Study – Hank | PetDx®
Case Study: Hank - Aid-in-Diagnosis

in a Boxer Mix with a Mediastinal Mass


9-year-old | Male Neutered | Boxer Mix | 63 lbs


Use Case
  • Site Challenging to Access
  • Owner Preference
Clinical Details

Hank presented for mild hyporexia, polyuria, polydipsia, and lethargy. Labwork with his veterinarian showed mild hypercalcemia, and thoracic radiographs showed a cranial mediastinal mass.

Case Study: Hank - Clinical Image

Lateral and ventrodorsal thoracic radiographs showing a cranial mediastinal mass

Why OncoK9 Was Performed

Cancer was suspected and oncology referral was advised, however the owner was hesitant to pursue oncology consult and preferred to start with non-invasive testing.

OncoK9 Result

Cancer Signal
Cancer Signal Detected
  • A Cancer Signal Detected result significantly increases the likelihood that cancer is present, but does not confirm the presence of cancer. This result should not be used as the sole basis for making important decisions such as treatment or euthanasia.
  • A confirmatory cancer evaluation should be performed to establish a definitive diagnosis.

Due to a Cancer Signal Detected OncoK9 result, a Confirmatory Cancer Evaluation was performed.


Cancer signal origin prediction: hematological malignancy (likely lymphoma or lymphoid leukemia)

Confirmatory Cancer Evaluation

May include any or all of the following:

  • Thorough clinical history
  • Thorough physical exam
    • Including oral and rectal exam
  • CBC and Chemistry
  • Urinalysis
  • Thoracic radiographs – 3 views
  • Abdominal imaging – ultrasound preferred
  • Radiographs of localized areas of bone or joint pain, if present
  • Tissue sampling of any detected masses or enlarged lymph nodes for pathological analysis

In some cases, advanced imaging (such as CT and/or MRI) may be indicated.

Cancer Workup & Findings

Diagnosis: Large Cell Lymphoma

  • Oncologist consultation pursued; ultrasound-guided FNA cytology of cranial mediastinal mass performed

Case Takeaways

Outcome: Veterinarian

OncoK9 results helped the veterinarian convince the owner to pursue immediate referral for workup of suspected lymphoma.

Outcome: Owner

OncoK9 results helped the owner decide to pursue oncology consultation and obtain a definitive diagnosis.

Outcome: Patient

Hank was able to start chemotherapy, which immediately palliated his clinical signs.

Case Summary

  • 9yo MN Boxer mix with hypercalcemia and cranial mediastinal mass
  • OncoK9: Cancer Signal Detected
    • Cancer Signal Origin Prediction: Hematological malignancy (likely lymphoma or lymphoid leukemia)
  • Confirmatory Cancer Evaluation recommended
  • Ultrasound-guided FNA cytology of cranial mediastinal mass confirmed diagnosis of lymphoma
  • Client pursued oncology consultation and chemotherapy was initiated, which caused immediate improvement of clinical signs

Join the Revolution in Early Cancer Detection for Dogs

If you are ready to add the OncoK9 multi-cancer early detection test to your veterinary practice, we would love to hear from you.