...Publication of Landmark... Clinical Validation Study...
OncoK9 Test Availability
Veterinarians in North America May Order Directly From PetDx or Through Our Partners
USA Test Code: S14493
CANADA Test Code: CS14493
To learn more about ordering,
contact your Antech representative
To set up an account contact our Sales Team
OncoK9: Clinical Validation Study
Clinical validation of a next-generation sequencing-based multi-cancer early detection “liquid biopsy” blood test in over 1,000 dogs using an independent testing set: The CANcer Detection in Dogs (CANDiD) study
The international, multi-center clinical study demonstrated that OncoK9® – The Liquid Biopsy Test for Dogs™ can detect 30 different types of cancer with a simple blood draw. The CANDiD study included blood samples collected prospectively from more than 1,000 client-owned dogs at more than 40 clinical sites across the United States, Canada, Brazil, the Netherlands, France, and Hong Kong between 2019 and 2021.
Results of the CANDiD Study – the largest clinical validation study ever performed in veterinary cancer diagnostics – were recently published by PLOS ONE, a leading peer-reviewed journal.
6 Million New Cancer Cases Per Year in Dogs
Cancer is by far the single most common cause of death in adult dogs. Like humans, dogs have a 1 in 3 lifetime risk of getting cancer, and approximately 6 million dogs are newly diagnosed with cancer each year in the United States. Older dogs, and certain predisposed breeds, are at higher risk of developing cancer. Cancer is typically diagnosed in dogs at an advanced stage, when treatment options are limited, and chances of a cure are low. Each year, cancer cuts short the lives of many dogs who might have enjoyed many healthy years with their families had the disease been detected earlier.
Cancer is a Disease of the Genome
Each cell in a dog's body contains billions of DNA "letters" that make up the dog's genome. Cancer develops as a result of the successive accumulation of genomic alterations (DNA mutations) over time. All cells release DNA fragments into the bloodstream, and DNA released from cancer cells contains unique genomic alterations that can be detected by liquid biopsy technology.
Early Cancer Detection in Dogs with a Simple Blood Draw
OncoK9® enables veterinarians to detect cancer in dogs with a simple blood draw. As a first-in-class multi-cancer early detection (MCED) test, OncoK9 employs cutting-edge genomic analysis that leverages next-generation sequencing (NGS) technology and proprietary bioinformatics algorithms empowering veterinarians to provide superior care to canine patients.
Most cancer tests are either invasive (like a tissue biopsy) or require special equipment (like imaging). OncoK9 requires only a simple blood draw. The sample collection can take place during the same visit when the veterinarian prescribes the test.
OncoK9 has demonstrated cancer signal detection in 30 different cancer types, including 8 of the most common cancers in dogs.
OncoK9 interrogates millions of cell-free DNA fragments in each blood sample, using sophisticated next-generation sequencing technology and bioinformatics algorithms to detect genomic alterations associated with cancer.
By identifying cancer signal in cell-free DNA extracted from a blood sample, OncoK9 may allow for earlier detection of cancer, before the onset of clinical signs.
How the OncoK9 Liquid Biopsy Test Works
A blood sample is collected that contains cell-free DNA fragments released from healthy cells and cancer cells (if cancer is present).
A centrifuge is used to separate the blood sample into 3 components: plasma, buffy coat, and hematocrit.
Cell-free DNA is extracted from plasma and an amplified DNA library is prepared for sequencing.
Next-generation sequencing of the DNA library generates detailed data for analysis.
The lab uses proprietary bioinformatics algorithms to identify cancer-associated genomic alterations.
A clinical report is sent to the veterinarian indicating whether or not cancer signal has been detected.
All OncoK9 testing and interpretation steps are performed at the PetDx central laboratory in San Diego, California.
OncoK9: Intended Use
OncoK9 is a multi-cancer early detection (MCED) test for the detection and characterization of cancer-associated genomic alterations in DNA isolated from canine whole blood samples, using next-generation sequencing (NGS) technology. As with any laboratory test, OncoK9 results should be interpreted by a veterinarian in the context of each patient's medical history and clinical presentation. The test is available by prescription only.
OncoK9: Annual Screening
OncoK9 is recommended as an annual screening test for all dogs starting at 7 years of age and potentially at younger ages for dogs belonging to breeds that are predisposed to cancer.
OncoK9: Aid in Diagnosis
OncoK9 is recommended as an aid-in-diagnosis for dogs in which cancer is suspected based on clinical signs or other clinical findings.
As an oncologist, I am excited about the ways in which the OncoK9 liquid biopsy test will benefit dogs, their families, and the veterinarians that manage their care.
PetDx in the Media
PetDx-led Team Clinically Validates Liquid Biopsy Test for Canine CancersView Media
Liquid biopsy test can detect 30 types of canine cancer, study showsView Media
This Blood Test Detects Cancer in Dogs. But Do You Want to Know?View Media
Clinical validation study for pioneering early cancer detection test for dogs is publishedView Media
Dog Cancer Early Detection Test Receives Clinical Validation for 30 Canine CancersView Media
Validation for early detection cancer screening for dogs publishedView Media
How PetDx Uses a Simple Blood Draw to Detect Cancer in Pets EarlyView Media
Clinical trial to evaluate OncoK9 liquid biopsy test for dogsView Media
IDEXX (IDXX) Collaborates With PetDx for Canine Cancer TestView Media
Multicancer detection in dogs with cell-free DNAView Media
Startups: Round to scale adoption of early-detection cancer test for K9sView Media
PetDx Raises $62M in Series B RoundView Media
PetDx Raises $62M To Get Canine Cancer-Detecting Tech To Vets Across The USView Media
Early Cancer Detection for Dogs is HereView Media
Join the Revolution in Early Cancer Detection for Dogs
If you are eager to incorporate breakthrough innovation into your veterinary practice, we would love to hear from you.
Be among the first to offer the OncoK9 multi-cancer early detection test to your canine patients.